I have been having exactly the same problem on several Fedora 27 systems for the last few days: [root@z97p ~]# cat /etc/yum.repos.d/adobe-linux-x86_64.repo [adobe-linux-x86_64] name=Adobe Systems Incorporated baseurl=http://linuxdownload.adobe.com/linux/x86_64/ enabled=1 gpgcheck=1 gpgkey=file:///etc/pki/rpm-gpg/RPM-GPG-KEY-adobe-linux [root@z97p ~]# dnf -v update Loaded plugins: builddep, config-manager, copr, debug, debuginfo-install, download, generate_completion_cache, needs-restarting, playground, repoclosure, repograph, repomanage, reposync DNF version: 2.7.5 cachedir: /var/cache/dnf Cannot download 'http://linuxdownload.adobe.com/linux/x86_64/': Cannot download repomd.xml: Cannot download repodata/repomd.xml: All mirrors were tried. ... Failed to synchronize cache for repo 'adobe-linux-x86_64', disabling. Last metadata expiration check: 0:00:55 ago on Wed 21 Feb 2018 08:43:09 GMT. --> Starting dependency resolution --> Finished dependency resolution Dependencies resolved. Nothing to do. Complete! I ran a packet capture to see what's happening on the network when I run 'dnf update': linuxdownload.adobe.com is a DNS alias for linuxdownload.wip4.adobe.com dnf connects to linuxdownload.wip4.adobe.com and makes the HTTP request 'GET /linux/x86_64/repodata/repomd.xml HTTP/1.1' The remote host just resets the TCP connection without responding Something's definitely not right at the Adobe end.
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