I had this problem on a MacBook and an iMac and corruption was only appearing through Lightroom, not PhotoMechanic or any other editing platform. It wasn't until I was editing on the road without an Internet connection that I realized the problem was not occurring. That led me to believe something was wonky with one of my other services that was always on and connected to the Internet that had any contact with my files... DROPBOX! Then I did some testing by putting my raw files in another folder - same hard drive, but not a folder connected to any type of file-syncing service. No issues. None whatsoever. Now this may not be the solution for everybody, but it worked for me. Frustrating to have another step added to the workflow - copy/pasting to a dropbox folder after editing, but hey, glad to have it figured out. Happy shooting!
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