For playback, there are no issues.
For interaction and simulation, as you indicate by the mention of a right-click and one button mouse, these issues have been handled for years within the Mac OS by use of the option-click in place of a right click.
There is support for other, more sophisticated input devices: such as a multi-button mouse, video scrubbers and scroll wheel mice; that are supported via manufacture supplied software that provides additional controls via the System Preferences Panel in OS X.
These features were also available in Mac OS 9 as Control Panels before USB became a common standard.