not open adobe Lightroom

The first thing that you should try is to switch off the GPU support from the Lightroom preferences and check if that helps to fix the issue. 

Go to Lightroom > Preferences > Performance tab > Uncheck "Use Graphics Processor" > Restart Lightroom. 

https://helpx.adobe.com/lightroom-classic/kb/lightroom-gpu-faq.html#troubleshooting 

https://helpx.adobe.com/lightroom-classic/kb/troubleshoot-gpu.html 

If Lightroom doesn't start correctly the please see "Solution 2" in the document behind the second link. 

Troubleshoot GPU issues | Lightroom Classic (adobe.com) 

Another step is to try to reset the Lightroom preferences. 

https://www.lightroomqueen.com/how-do-i-reset-lightrooms-preferences/ 

It's recommended to backup your preferences before you reset the preferences to the default settings: 

https://helpx.adobe.com/lightroom-classic/kb/preference-file-and-other-file-locations.html 

Take also a look here: https://community.adobe.com/t5/lightroom-classic-discussions/quick-tips-how-to-give-full-disk-access-to-lightroom-classic-on-macos/td-p/12913413 and give Lightroom full access rights.

If this doesn't help we need more informations about your environment. 

Which operating system do you use? 

Which version of Lightroom do you use? 

Please post the exact version and not only phrases as "recent", "latest" and so on. 

Do you get an error message? If yes, please post the exact message or an screenshot.