Amal, that suggestion did not work for me. Changing that setting in preferences does not impact the user interface at all. I restarted Acrobat as well as my computer, and also adjusted the scaling in Windows, but no effect on the Acrobat UI.
Does it matter that I am using a networked computer? Right now my display resolution is set to the recommended 2560x1440 for this monitor, and scaling is set to 125%.