So we have upgraed to the 64bit version of Acrobat (Continuous Release | Version 2022.001.20117 | 64-bit). Our application uses the IAC interface to draw PDF into one of our application windows using PDPage.DrawEx. This worked fine at 32bit but now at 64bit, Acrobat is always drawing into the upper left corner of the desktop (outside of our appliations window). We then decided to try the samples that ship with the toolkit and it exhibits the same behavior. The sample is the StaticViewVC in InterAppCommunicationSupport\CSamples directory. Compile it 64bit and you will see the issue, compile as 32bit and it behaves correctly.
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