There was an error opening this document. The file cannot be accessed by the system.

[MartyGoGo]

I'm unable to open some PDF files that I previously worked. The ones I'm having an issue with have an "X" on the lower left corner of the PDF icon. When I try to click on them, I get the following error: There was an error opening this document. The file cannot be accessed by the system. 

I've also tried accessing the files thru the Adobe Cloud but it gives me the following error message: The file cannot be accessed by the system.
Again, these are files that were uploaded correctly and which we've worked on several times, without a problem until a few days ago. Now, thousands of files cannot be accessed and its causing me to have a  slight panic attack.

How do you fix this and why is this happening in the first place?

[Cheyenne29715360jexz · Accepted solution]

I have solved the issue. Hopefully this can help someone else with the same issue. 

When you are in the folder containing the documents you need (it can even be the first folder you click into) click file, then options, and then click the button at the bottom "restore defaults". I was then able to open my files. 

[jackiec76248641]

I had the same problem.  I had to log OUT of Adobe, restart the computer, then sign back in.  It seemed to have reset the security settings and I can now access all the files

[Cheyenne29715360jexz · Accepted solution]

I have solved the issue. Hopefully this can help someone else with the same issue. 

When you are in the folder containing the documents you need (it can even be the first folder you click into) click file, then options, and then click the button at the bottom "restore defaults". I was then able to open my files. 

[Xiannon38955229ueg6]

This is a late response I know, but I just want to help whoever can be helped because I had the same issue and it drove me crazy so I know if it drove me crazy and I'm looking at all the responses. It drove others crazy too, but my resolution actually ended up being not to go through the creative cloud, Adobe acrobat app at all, I was able to open up my file through Adobe acrobat online and just sign into my creative cloud online then I was able to open up my document that I couldn't open up. I kept getting the error that I couldn't open it up. The file was nowhere to be found , but thank God, I was able to open it up online through the desktop I hope this helps somebody because I was certainly looking for help.

[charles_8225]

I helped someone with this issue recently that had trouble opening files on a network drive- and in our case it was a problem with the total pathname length (folders + filename) exceeding a limit of 256 total characters.  In this case she had a lot of folders categorizing her work and had a very lengthy filename.  When I reduced the filename under this limit the file opened normally.

[Whimsical_adventurer5632 · Accepted solution]

I was able to fix it. My problem was with Dropbox, not Adobe. Long story short, I had to click on the teeny tiny icon in the bottom right toolbar and let it sync. It seems I hadn't let it sync since getting my new computer a month ago. Crisis averted. I just wish it would have updated on its own.