My newly reinstalled Adobe Reader DC will not open, nor can I open any PDFs with it

[#1]

It started as failure to open PDFs;  I uninstalled and reinstalled AR DC, still PDFs on emails in MS Outlook would not open. Then I tried to open PDFs in Documents folders - got a message "Windows cannot find [file name clicked on]. Make sure you typed the name correctly then try again".  I got the Adobe Cleaner which cleaned up and uninstalled AR DC;  reinstalled it again from Adobe website.  Still cannot open any PDF anywhere with AR DC.  But can open PDFs perfectly OK with Avast Browser and Google Chrome.  Then found I cannot even open AR DC as a free standing program by clicking in program list, and right clicking does not offer an 'open' option.  So completely stuck!  Help please.

Installed on Dell Inspiron using Windows 10 Home, build 1903, OS 18362.836

[#2]

It started as failure to open PDFs;  I uninstalled and reinstalled AR DC, still PDFs on emails in MS Outlook would not open. Then I tried to open PDFs in Documents folders - got a message "Windows cannot find [file name clicked on]. Make sure you typed the name correctly then try again".  I got the Adobe Cleaner which cleaned up and uninstalled AR DC;  reinstalled it again from Adobe website.  Still cannot open any PDF anywhere with AR DC.  But can open PDFs perfectly OK with Avast Browser and Google Chrome.  Then found I cannot even open AR DC as a free standing program by clicking in program list, and right clicking does not offer an 'open' option.  So completely stuck!  Help please.

Installed on Dell Inspiron using Windows 10 Home, build 1903, OS 18362.836

[#3]

I am having the exact same issue.  My Office products quit working at the same time, giving the same error message, and their technical support edited my registry to fix it. I have uninstalled and reinstalled mulitple times, including with the Cleaner. This is the error message:error when trying to run Reader

[#4]

I am having the same issue.  Office products are working, but I am unable to open Acrobat Reader DC.  I have uninstalled, installed, uninstalled, installed, uninstalled, etc including with the Cleaner.

I am on a DELL laptop and version 1903.

Error message says: Windows cannot find c:\program.files(x86) ..... My techsmith program are also impacted.

[#5]

So what do we do? I have the same issue since this morning. 

[#6]

I would also like to know, and yes, it started this morning!

[#7]

Same issue here! Reinstalled Reader multiple tiems & Office products all stopped working.

My password manager did too!

Latter company thinks it's due to a Windows update...

[#8]

But my Windows update wasn't installed at that point, just downloaded. I thought about that, too, because it started yesterday (Tuesday) morning.

[#9]

yay! Fixed it. Disabled the antivirus (AVG) & it installed OK. Coincidentally, there was an update to the A/V so maybe there was a bug in it 😉

Hope that helps.

[#10]

This morning I tried to open a PDF and was rewarded with the new user screen for my Reader!! Still no idea what was wrong, but somehting, some place appears to have been fixed.