I upgraded many users at my company from 1080p monitors to 1440p monitors.
The UI and font is far too small in most programs at 100% windows UI/font scaling so we scaled up to 125% on UI and Font size.
Virtually every program we use, except a couple very old ones scaled perfectly and function perfectly as well.
The only program that is unusable at 125% is Adobe Acrobat Pro DC, and Adobe Reader DC.
Every single PDF has blurry vector linework and text at 125%, but is crisp and perfcect at 100%.
Screen shots attached.
I tried rightclicking the .exe for Acrobat and selecting "compatability" and changed all of the possible UI scalling options. I logged out and back in after all changes. None of these windows UI scaling options fixed the issue. I also trying checking the Resolution and "smooth text" monitor optimization settings to no avail.