We have deployed Adobe Document Cloud PDF Experience for Office 365.
The user has set the default browser to IE 11 (for using legacy business applications).
There are PDF documents in a SharePoint Online document library, and the user wants to open them in Adobe Document Cloud, so he can markup and annotate.
Using IE11, he does see the option to Open in Adobe Document Cloud when he opens his OneDrive webpage, and then uses the left navigation pane to navigate to the SPO document library.
But when he browses directly to the SharePoint Online site, and then opens the SPO document library, then he does not see the option to Open in Adobe Document Cloud (only sees Open in browser)