Thanks for your reply. I am using a MacBookAir and the most updated Adobe XD version. Here are some videos trying to show the problem. The first example is using the same component on a regular vs. overlay screen. The second is showing how at first the dropdown responds by closing, but then it will not open again. I hope that is helpful. Let me know if you would like more info.
To figure this out we need to see how the whole thing is set up. If you can send a part of the .xd file, with some problematic interactions / components, that would be great. You can upload somewhere and post the link here, or send it to me via PM.