I've inadvertently double-clicked on a recent file from the XD Home window to open the file, and while the intended file does open fine, a separate file window opens which continuously shows the loading bar (screenshot below). Everything in this window is disabled, including the window control (X) that should close the file.
The only way I can close this unresponsive file/window is via the Task Manager by ending the entire Adobe XD app.
There doesn't seem to be any noticeable performance issues with keeping this open while I work on other files, but it is extremely annoying.
Sorry to hear you are experiencing issues with XD while opening the file. We would request you to please sign out of Creative Cloud and XD and sign back, restart the machine and then sign back in.
Let us know if that helps.