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Changing the margins on a layout guide symmetrically currently seems to be virtually impossible. Rather than the column widths changing to compensate, when editing side margins, the whole guide shifts across the artboard.
XD version: 18.104.22.168
That is known issue. Please review https://community.adobe.com/t5/adobe-xd/making-layout-grids-is-very-unintuitive/td-p/11208443?cid=10...