Hi, William. Can you provide some more details about your setup? Are you using a 3rd party device (like from AJA, Blackmagic, Avid...) to send video out via Transmit? Or to a secondary/tertiary... monitor connected to your graphics card?
I'm using a 2021 Macbook Pro 16 inch, connected to a USB C monitor via USB C, using the larger external monitor as the main display and the macbook display as my video preview. weirdly today it has been working, though
If it should stop working again for you, the first thing that comes to mind is to check to see whether part of the application's UI might be spilling over onto the secondary monitor. If the UI on the big monitor bleeds over onto the secondary monitor, that can interfere with Transmit functionality.