Without any system information we can't really tell you much. Plug-ins failing to load typically points to sevewre compatibility issues like missing DLLs or even incompatible processors. As a start, try to reinstall the program with escalated user priveleges, i.e. as an administrator or a different user. For anything beyond that much more info would be required.
I'm running the AE on Win10 Enterprise (MS WVD) boxes powered by Intel Xeons. I have tried to run them with elevated user priveleges but the problems remains the same. I haven't added any plugins during installtion process.
The interesting thing is in my another machine which has the exact same config, its running smoothly but in the PROD machines, it doesn't like to launch.