You haven't said what version of After Effects you're using (the exact version number, not just the year), whether this happened after updating, if it happens on other projects, or even what operating system you have, so there's not much to go on. The only things I can reccomend trying are first, seeing if there are any updates, and second create a new project and import your problematic .aep into the new one. This often fixes issues with projects that have corrupted header data, but it preserves your comps and animation.
Is there a reason you're still on 2020? There have been some major performance improvements in the last year. Even 17.0 isn't the latest version of 2020, there were several patches of 17.0, so the best thing to do is update. You can also trash your preferences, but 17.7 was the last released version of 17.x, but I recommend installing AE 22, which can be installed alongside AE 20 (as long as you make sure to uncheck the box to "Remove Previous Versions" when you upgrade).
I wonder if there's a permissions issue, those can cause crashes because files can't be read properly. From the "Animation" menu you can apply a preset directly, as opposed to doing it from the Effects and Presets panel, so let's try this: Can you find the .ffx (or any one since they all seem to be causing a problem), move it to your Desktop, then apply it manually via the "Animation" menu?
Unfortunately, I can't say then. It could very well be a permissions issue. Since you didn't have AE 22 installed previously, one good way to confirm if the D drive installation is the issue is to reinstall AE 22 on your C drive and try to apply one of the default presets.
Also, just in case you haven't, restart your computer. Perhaps you've already done this, but this simple step is often overlooked and can fix a lot of problems.
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