Hello,
As the topic say, I did several tests comparing the same Desktop App published with AIR 25 32 bits versus AIR 25 64 bits.
This app have 7 MB SWF file size, more than 200 views and more than 250 models.
The heaviest task takes about 500 MB ram (exporting a large report with more then 100 pages to PDF on client side).
The app takes exactly the same amount of time on 32 and 64 bits on all tested tasks and I didn't saw any behaviour diference, so from my tests about 64 bits version I consider good to go BUT soon I will use my first Desktop ANE, so supporting ANE's it's a mandatory requirement.
Regards,
Hugo.
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