Shortcuts are not working
It works when I restart the program but it stops working a few minutes later.
like I need to press B button to use a brush or press Q to resize.
reset your preferences (and you might want to backup your shortcuts if you've customized a lot of them), http://helpx.adobe.com/flash/kb/re-create-preferences-flash-professional.html
C:\Users\\AppData\Local\Adobe\Animate CC \ and
/Users//Library/Application Support/Adobe// and
Try a uninstall and reinstall.