Shortcut not working?

[appleappleanimate]

Shortcuts are not working 

It works when I restart the program but it stops working a few minutes later.

like I need to press B button to use a brush or press Q to resize.

[kglad]

reset your preferences (and you might want to backup your shortcuts if you've customized a lot of them), http://helpx.adobe.com/flash/kb/re-create-preferences-flash-professional.html

or remove

Win:
C:\Users\\AppData\Local\Adobe\Animate CC \ and
C\Users\\AppData\Roaming\Adobe\Animate\\

Mac:
/Users//Library/Application Support/Adobe// and
/Users//Library/Preferences/Adobe/Animate//

[Nicktendo28]

Try a uninstall and reinstall.