I use Audition CC (currently on 11.0.2.2) with an Audient ID14, and I work as a voiceover artist.
I nearly always record straight to the single track, not multitrack, waveform viewer. For my studio setup, I need my Audio Channel Mapping screen to be set to:
1 [L] (Mono) Analogue 2
2 [R] Analogue 1
Whenever I unplug and replug my audio interface, or power-cycle my computer, these settings reset to the default of:
1 [L] (Mono) Analogue 1
2 [R] Analogue 2
Audition should save that setting in it's Settings folder when you close down Audition. However it appears that it doesn't.
Confirmed this occurs on latest version of Audition (v12) as well in the forum:
https://forums.adobe.com/message/10689121#10689121