I have some 16 bit scans that I have been working on in ACR 17.2. I have done very extensive retouching of the damage to the negative using the Generative Ai removal tool because this is easily the best result. File size is about 158MB. However it is incredibly slow in a way that it isn't when I do this on my DNG camera files. Now, returning to the file it won't open again in ACR, I just get a beachball. I left one "opening" overnight and it was open the next morning but I don't know how long it took to open. The file that has the very extensive spotting wouldn't build a preview unless left overnight and now will not open.
I am bewildered as to what is going on. System is Macbook Pro M3 Max running Sequoia 15.3.1 with 36GB ram 1TB internal and accessing the files on an external NVME 4TB SSD