Hovering over profiles and presets changes the histogram but the live preview doesn't update till I click. It works in Lightroom and Lightroom Classic but not in ACR for some reason. Hardware acceleration is enabled.
First, try disabling GPU in the preferences (Preformance tab). Any better? If not, recalibrate and build a new ICC display profile, the old one might be corrupted. If you are using software/hardware for this task, be sure the software is set to build a matrix not LUT profile, Version 2 not Version 4 profile. If turning OFF GPU works, it's a GPU bug and you need to contact the manufacturer or find out if there's an updated driver for it. Also see: https://helpx.adobe.com/photoshop/kb/acr-gpu-faq.html
Author “Color Management for Photographers" & "Photoshop CC Color Management/pluralsight"