First, try disabling GPU in the preferences (Preformance). Any better? If not, recalibrate and build a new ICC profile, the old one might be corrupted. If you are using software/hardware for this task, be sure the software is set to build a matrix not LUT profile, Version 2 not Version 4 profile.
Author “Color Management for Photographers" & "Photoshop CC Color Management/pluralsight"