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When I open RAW files in Lightroom, Elements and Photoshop, images open in Develop module with rows of red and black pixels throughout the image and blocks of random colors. I uninstalled/reinstalled Lightroom and installed a new graphics card with no improvement. JPEG files open correctly. This problem also occurs with Elements and Photoshop. If I open a RAW files in Luminar and export it to Lightroom, the problems disappears. I tried changing settings in Lightroom, to no avail. This problems began with Camera RAW 12.3 and continues with 12.4. I also converted RAW files to DNG and the same problem occurs. This problem is present with RAW files from various camera formats, Olympus, Nikon and Sony.
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Try clearly the ACR cache and try again; any difference?
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Yes,
And no difference with GPU on or off?
Next try recalibrating the display and making a NEW display profile.
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What OS?
Do you have another computer you can try?
You recreated the display profile? What software and settings? Avoid version 4 profiles and LUT IF the software had such options.
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I suspect the GPU on your one machine. Otherwise the profile issues would be seen on both systems, assuming you're using the same settings. It's odd that GPU off still shows the issue however.
You could try reinstalling but I don't think that will help. If all else fails, you'll have to give that a try.
You could try resetting preferences first.
https://helpx.adobe.com/lightroom-classic/help/setting-preferences-lightroom.html
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