What version of CFMX7 are you using exactly - 7.0, 7.01 or
7.02. If not using 701 or 702 upgrade. Datasources are stored in
neo-query.xml in cf_root/lib. How many datasources are you using?
Could you be putting in some weird syntax that is corrupting the
xml file? You could take a look at the file in firefox or a xml
viewer and make sure things look consistant datasource to
datasource.
Are these the only settings that disappear or revert back to
default settings? If so, are you using a J2EE version of
ColdFusion? If so, on what appserver?