You shouldn't be involved with such fine-grained details.
Unless for specialist applications, such matters are better left to
Coldfusion and MySQL.
In my experience, installing MySQL for Coldfusion, with
everything set to default, works for almost every case. CF8 has an
in-built driver for MySQL 5.1.x. If you're on CFMX7.x, the
procedure is as follows.
Stop Coldfusion. Download the Connector/J jar-file for MySQL
5.1.x from MySQL.com. It is usually wrapped in a zip file. Extract
the file and copy the jar-file to {CF_ROOT}/WEB-INF/lib. Restart
Coldfusion. When you configure a datasource in the Administrator,
choose the "other" option as the driver type.