I use creative cloud with lightroom and photoshop installed. One day I woke up to find my 2TB NVMe drive full, of which several disk analyzers confirmed only ~90 GB was actually in use.
It took about 5 days with a custom app running (no Windows app can process a directory with that many files) to remove a bit over 3 billion empty subdirectories from the Adobe directory:
The subdirectories had large integers as their names. Even after removing all the subdirectories, Windows 10 didn't recognize the removed subdirectories as free space which forced me to reformat the drive.