Can I safely clear AppData files?

[Swandive stream]

I have a multi-hard drive computer with C being the smallest intended for system files only but Adobe keeps putting cache etc on there by default and filling it to capacity. I've been re-routing the cache storage to another drive manually but what can I safely delete from C after transferring? It's frustrating, it isn't that uncommon to have this multi-drive arrangement now as solid state drives are faster but more expensive than traditional hard drives and the no space on C issue is blocking updates. 

[Jeff A Wright]

FasterTrack, please see my previous response to your question about Libraries in your earlier discussion at https://community.adobe.com/t5/creative-cloud-services-discussions/how-do-i-prevent-libraries-from-b.... 

You may need to use a different computer if the current computer does not meet your needs for running Adobe Creative Cloud software.