I downloaded Creative Cloud and Premiere Pro then I ran both through virustotal.com and both got detected as malware but when I used the anti-virus on my pc it didn't detect it as malware. Should I be worried?
VirusTotal is an aggregating service. It does not produce any verdicts of its own. We'd need to know which specific virus scanners think they detected malware and what the exact error message is. Then report it to the virus scanner vendor themselves.
As John noted, it's very likely a false positive. VirusTotal tests a file with multiple virus scanners and if, let's say, only two out of those show a warning, it's safe to assume that those two are in the wrong.