New Mac, Big Sur, 11.2.1. Had been using for a few days, went to eyedrop, new Mac said I needed to grant permission for this step and that a quit would be needed. Opted for a whole restart and upon return AI was in the dock but didn't respond to clicks. Not even beach ball. Uninstalled CC app and then unable to get it past the disk image phase of the reinstall. Same thing, just now on the whole app.