After a few jams in Lightroom the Creative Cloud desktop reported it needed a repair. Ik stopped the repair when it didn't seem te work: 45 minutes it remained on 52%. The same happened when I tried to reinstall the app.
What issues, if any, can I expect using my Adobe apps without the Create Cloud Desktop?
Make sure that you have all Windows updates that are available.
The one thing that was causing it for me, believe it or not, was that I needed to do a clean installation of the latest Studio graphics driver from the NVIDIA website. After doing that and restarting, all was OK.