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Adobe's solution does not help. this issue aroze after upgrading to windows 10 and office 365
Error code P48: Unable to access a critical file/directory
Error code P48 indicates that Creative Cloud can't access a file or directory that is required for installation.
Click Retry to try accessing the file or directory again"
first try, resetting the cc app: To reset the Creative Cloud desktop app, make sure it's in the foreground, then press:Win: Ctrl + Alt + RMac: Cmd + Opt + Rif that fails, do a clean cc install:uninstall every cc app including preferences, https://helpx.adobe.com/creative-cloud/help/uninstall-remove-app.htmlthen uninstall the cc desktop app, https://helpx.adobe.com/creative-cloud/help/uninstall-creative-cloud-desktop-app.htmlclean your computer of cc files per http://www.adobe.com/support/contact/cscleanertool.htmlrestart your computer (don't skip this)reinstall the cc desktop app, https://creative.adobe.com/products/creative-cloud.if you're unable to install the cc desktop app at this stage, use an administrator account (solution 4 here, https://helpx.adobe.com/creative-cloud/kb/creative-cloud-missing-damaged.html)use the desktop app to install your cc programs/trials