I'm currently setting up a booking system using Dreamweaver
and ColdFusion and SQL Server Express for a Guest House here in
Ireland. It allows people to search the database for an available
room, book it based on dates, etc.
You'll need to plan your database, think about how people
will interact with the application and what you want them to do.
What are they going to do, make sure you detail every step they
need to book the room. I plan on paper first and then create a
database.
I find ColdFusion a easier language to learn than PHP, VB.NET
or C# especially if you have no programming background.
Also, get a good understanding of SQL (language to pull data
from the database).
Good lick.