When I or one of my colleagues attempted to run the updater for FrameMaker 2015 Update 2, the installer stopped and displayed the following message: "There was an error installing this update. Please quit and try again later. Error Code: U44M1I210"
The problem seems to be related to permissions. An Adobe support record (Error U44M1I210 when installing Adobe Creative Cloud or Creative Suite 6 updates) suggests creating a new user with administrator permissions. Although I and the colleague who experienced this problem were already logged in as administrators, in my colleague's case, someone from IT created a new user with (the same) administrator permissions, which solved the problem.