Unable to Save - save dialog box unresponsive

[markwm]

I'm unable to save my documents locally, the save window isn't fully responsive.

I can select a format but everything else doesn't respond to mouse clicks. 

[Chad Chelius]

Not to overstate the obvious, but have you tried quitting or force quitting Illustrator and relaunching? May even help to reboot your computer.

[Ares Hovhannesyan]

Do it happen only with Ai? You can try to reset Ai preferences from Preferences dialog.