Seem like a few on here have had this issue since the update for 2021, lets find a solution for this.
As title describes, functions that used to have a shortcut by double-clicking do not work. When double clicking any object, it does not isolate. Nor does double clicking on text with the selection tool enter text editing mode. All functions that use double clicking are no longer operable.
Every program in the Adobe suite does this after the 2021 update. Double click works in every other program in Windows, so it's not a mouse setting.