Could it be that you have enabled "Draw and Edit in Realtime" (I don't know the right english term for that) in Preferences --> Performance?
Try to uncheck this point - if you work with guides.
Or try to use temporarily Ctrl+E (View --> Preview on CPU)
or Ctrl+Y (Outline View)
A guide line has no fill and no stroke. Maybe that's why it is invisible while moving.
This works, thanks.