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It seems to load then just stops before the workwindow opens. Message says (Not responding) I have uninstalled illustrator and reinstalled and have the same problem.
Hi. Have you tried resetting the preferences? https://helpx.adobe.com/illustrator/user-guide.html/no/illustrator/using/setting-preferences.ug.html
Reset Prefs Thoroughly (Mac)
OOBE RESET MAC
If that does not resolve your issue
Use the Creative Cloud Cleaner to fully remove your app & prefs then reinstall
I am running on Catalina also. Don't go to Big Sur.