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If it's possible to have a lock toggle for individual appearance items it would be helpful. Being able to maintain items you want and still use the eyedropper feature to pick up attributes from other objects it would be helpful.
You can add to appearances when using graphic styles. https://helpx.adobe.com/illustrator/using/graphic-styles.html#apply_a_graphic_style
To have this with the exedropper tool, maybe you want to make a feature request? http://illustrator.uservoice.com