Yes it's safe to delete these files. Make sure that you don't have any need to recover any InDesign file as that happens using the data stored in these files/folders. In order to be safe you can move these files for sometime to an alternate location and if you see they are not needed you can delete them eventually. See the following link for more details about what these files are
Thank you for your reply. It's perfect, I delete. Good day Manan.