Which OS version and how much RAM and spare hard disk capacity do you have?
Maybe try resetting the InDesign preferences back to the factory defaults:
1) Close InDesign 2) Double click on Adobe InDesign's icon to launch it 3) QUICKLY hold down Ctrl+Alt+Shift. (for Windows) or CTL+OPT+CMD+Shift (for Mac OS X) 4) When a dialogue appears, asking you “Delete InDesign Preference Files?” Click Yes. If you don't see the question repeat the procedure again