Hi Leah,
just adding a few links to Adobe kb and help pages:
Apps that run using Rosetta 2
Last Published: December 8, 2020
You can install the following apps on computers powered by the Apple M1 chip. They run using Rosetta 2 technology. The apps may initially take longer to open while Rosetta 2 translates them for use in your M1 computer.
…
https://helpx.adobe.com/download-install/kb/apple-silicon-m1-chip.html
Wheras if I look into System Requirements for InDesign 2021 the Apple M1 chip is not mentioned at all:
InDesign system requirements
Your computer must meet the minimum technical specifications outlined below to run and use InDesign.
Applicable for: October 2020 (16.0) release.
macOS
Processor: Multicore Intel processor
Operating system
macOS version 11 (Big Sur),
macOS version 10.15 (Catalina),
and macOS version 10.14 (Mojave)
https://helpx.adobe.com/indesign/system-requirements.ug.html
Regards,
Uwe Laubender
( ACP )