I've found a solution to a problem many others seem to have reported - but it does involve a work-around, suggesting the Adobe Photoshop Lightroom team need to fix a bug.
When a large number of Develop Presets are loaded into Lightroom (in my case, over 500), the Library Module, and strangely, to a lesser degree, the Develop Module run very slow.
Having performed some troubleshooting, I discovered the reason for the slowness was a CPU spike. On my iMac 3.4GHz with 32Gb RAM, NVIDIA GeForce GTX 680MX with 2GB, and 1TB Fusion Drive, the CPU would go over 100%, while the disk and memory allocations were low. I run Mavericks 10.9.2, so it's not a matter of an out of date OS. This occurred whether I had 10 images or 10,000 images in the catalog (I tested various scenarios).
I read on a forum that the number of Develop Presets could affect performance, so deleted the majority of them (backing them up first) to see if it would make a difference. I reduced the number of presets to less than about 100, and the performance increased INCREDIBLY and INSTANTLY.
So, it would seem to me there is a bug in the way the Develop Presets are being indexed in Lightroom. Hopefully, this is something the team can find and fix very easily, as it should be easy enough to identify the root cause and reproduce the problem.
Please, Adobe - release a fix for this in the next point release. It is disappointing not to be able to keep all my Develop Presets in a single session. My work-around is to exit Lightroom, copy in the Presets I need for a job, then start the program again. Obviously not ideal.
Many thanks,
Matthew