Effect of a profile disappears when I return to the library module

[rsynapse_rm]

After working with a particular profile in Lightroom, I went back to the library module, and the effect of the profile disappeared.  Furthermore, while in the development module I imported the profile-changed image into Photoshop, and when I did that, the effect of the profile disappeared.  Help.

[GoldingD]

Any particular profile, or any profile?

[johnrellis]

In particular, is the problem profile a creative profile (file name ends in .xmp)?