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Can anyone help me understand what is going on with my LR? It has literally only just started now and I've been editing for over 10 years. It is showing different colour & saturation on different parts of the screen. If I change to another image, it will then switch and only over saturate the one selected whilst still looking normal in the main area.
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You've posted a Lightroom Classic screenshot in the Lightroom Eco forum. Moving to Lightroom Classic.
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Maybe you have a bad monitor. Or a corrupted monitor profile.
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First, try disabling GPU in the preferences (Performance). Any better?
If not, recalibrate and build a new ICC display profile; the old one might be corrupted. If you are using software/hardware for this task, be sure the software is set to build a matrix, not LUT profile, Version 2, not Version 4 profile.
If turning OFF the GPU works, it's a GPU bug, and you need to contact the manufacturer or find out if there's an updated driver for it. This is why disabling GPU is an option as more and more functionality moves to the GPU in newer versions of many Adobe products. Disable third-party graphics accelerators. Third-party GPU overclocking utilities and haxies aren't supported.
Also see: https://helpx.adobe.com/lightroom-classic/kb/troubleshoot-gpu.html
If the GPU and display profile isn't causing the problem, see:
https://helpx.adobe.com/lightroom-classic/kb/lightroom-gives-error-preview-cache.html