ctrl e does not work to "Edit in Photoshop" from my Lightroom

[jamesp19793524]

the "Edit in Photoshop" is greyed out in my Lightroom.

I've checked the see if all my Adobe programs are up to date. 

I've closed both programs, restarted, and then opened Ps first, then Lr. 

What is my next option?

[Rob_Cullen]

Grey 'Edit-In' menu may be caused by-

1) The photo is 'missing'. Lightroom does not know where the original photo is stored- it has been deleted, renamed, moved, by the OS outside of Lr.  Grid view thumbnail is showing a [!] on the border? (or possibly a corrupt file)

MISSING PHOTOS

2) You are using Smart Previews and the original file is not connected to the computer or available to Lightroom. (eg. external usb drive not connected). Plug in the external drive- check that it is using the same Name/Letter as before. (Also see the link for Missing photos)

3) Lightroom and Photoshop are not linked correctly in Registry/plist.  See this link-

EDIT IN Photoshop command missing