When I select a photo in LR and request "Edit in Photoshop 2021", Photoshop 2021 launches but the file does not open. However when I configure Photoshop 2020 as an additional external editing option, it prompt me with "Edit a copy with Lightroom adjustments" or "Edit original", if I select "Edit copy" it will load the file in Photoshop 2021, if 2021 is running.. If I select "Edit original", the file will not load.
I have both Photoshop 2021 and 2020 installed. Even though I pointed to photoshop.exe in 2020, I have 2021 running and it used 2021. I was opening a *.dng file (which is RAW). Here is my LR Preference: