Over the years that I've been using lightroom I have had to add hard drives to get more space. Now I have a 14TB drive and I want to migrate everything from my multiple small hard drives to the new single hard drive. Lightroom is working fine and the catalog is working with all of the smaller drives now.
I assume you mean Lightroom Classic. Instructions for moving photos to another drive, while keeping Lightroom Classic aware of the photos' new location, are in "Part 2 — Updating Folder Location" in this document.