Do you mean from the Desktop Folder of your hard drive and what you see when you sit in front of your computer?
Please post this.
Please Consider including the following in your question: Adobe product and version number Operating system and version number The full text of any error message (s) What you were doing when the problem occurred Screen shots of the problem Computer hardware, such as CPU; GPU; the amount of RAM; etc
On the newest Mac OS there are far more restrictions as to where programs have access. One that is restricted is the Desktop.
Change the settings found here.
And a more Detailed description of what you are trying to do.