Lightroom doesn't do anything when i select any "edit in" choices all of the sudden. Not sure what's happening, I've updated all adobe programs, updated computer, have a newer Mac book pro, using the original photo. The program doesn't do anything when i try to select edit in photoshop or portraiture.
Since you haven't provided any relevant information, I will offer one possible suggestion. IF you are editing smart previews with the master images not available then the option to edit in Photoshop will not be available to you. You must be able to have access to the master images in order to use that feature. If that isn't the case, then please provide some relevant information about your system, your operating system, the actual version of Lightroom you are using, when this problem started, etc.
Smart previews have nothing to do with this. If the original image is missing, then the "Edit in..." menus will be dimmed. That is not the case here, so something else is going on. I would first try to reset the preferences. If that does not help you could try uninstalling Lightroom and reinstalling it: