Hi, I'm having the same issue. I'm on Windows 10 Pro and LRc v10.01, Camera Raw 12.1. I've noticed that it's taking a long time to boot (not responding) initially and also during normal use. It eventually works but has become so slow it's getting unworkable.
Already try it. Also tried log off, log in creative cloud, donwgrade to other Lr Versions, disable graphic processor, adobe cleaner tool... and any tips that I found. __ For now I am keeping my Lr opened (opened trhought Lr catologh phile) and praying not to loose my work